isoflavones




Safety of isoflavones

There are studies which try to prove that isoflavones are not safe. These studies are mostly based on experiments with animals and studies in-vitro (where tests are done in cells grown in test tubes). The interpretation of these results and the extrapolations to humans is questionable. Most of the isoflavones dosages which were used are very high compared with normal usage. The following issues are often raised:

Isoflavones can cause breast cancer

Isoflavones are similar in structures as human estrogen. Therefore it's easy to make the theory that isoflavones are not safe for women with a cancer breast risk.
Test with Raloxifene, a molecule similar to isoflavones, proved that they protect against breast cancer. Animal studies also show that fermented soyfood, miso or soy protein significantly improve the chemotherapeutic effects of Tamoxifen.
In a in-vitro study the isoflavones genistein inhibited the growth of breast cancer cells. Genistein had a synergistic effect with tamoxifen.
Based on the currently available evidence there's no reason that consuming soy may cause breast cancer. With isoflavones supplements it's easy to take too much isoflavones, which is not possible when consuming soyfoods. Not much data is available on the overconsumption of isoflavones supplements. It's recommended not to consume more tan 50 mg isoflavones as supplement per day.

Isoflavones and infant development

In the United States, about 20 percent of the infants are given soy formulas. It has been suggested soy formula could accelerate puberty and cause developmental and reproductive abnormalities and thyroid disorders. Preliminary research in the US found that isoflavones of soy infant formula do not disrupt infant development, despite concerns from some scientists that the isoflavones could act like female hormones in infants. Studies at the Arkansas Children's Nutrition Center have found no apparent long-term positive or negative effects of feeding infants soy versus cow's milk formula.
Ryowon C. et al investigated the effects of soy isoflavones on babies and concluded that soy-based formula could be used for long-term feeding of babies.

Adverse effects on boys or men

Because isoflavones are similar in structure than the 'female' hormone estrogen some people are very quick to make a link between isoflavones and development of breasts and adverse effect on fertility of boys and men. However, animal studies did not find any change in fertility. Studies on men taking isoflavones supplements showed no effect on plasma hormones or semen quality. Other studies showed no adverse effects on sperm quality in mice fed with genistein.

Isoflavones and thyroid

The hormones produced by the thyroid are needed for the growth. Soy appears to have potential effects involving the thyroid gland. Individuals with impaired thyroid function should discuss the intake of isoflavones with their phycisian because isoflavones have been observed to reduce absorption of thyroid medication. Studies have shown that infants fed with soy formula have the same development as infants fed with cow milk formula.
Studies showed that soyfoods, and their isoflavones, are associated with a reduced risk of thyroid cancer. Some studies hint that isoflavones may inhibit the function of the thyroid gland, though this inhibition may only be significant in individuals who are deficient in iodine. Therefore people who consume large amounts of soy or isoflavones should make sure that their intake of iodine is adequate.
Other studies on healthy humans have found that soy and isoflavones had no effect on thyroid hormone levels and actually increased levels in some cases.

More literature about safety of isoflavones

Chang HC et al. Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. Toxicol Appl Pharmacol 2000;168(3):244-252.

Cummings SR et al. The effect of Raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. JAMAI 1999;281:2189-2197.

Tanos V et al. Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro. Eur J Obstet Gynecol Repr Biol 2002 May 10;102(2):188-94

Mitchell JH et al. Effect of phytoestrogen food supplement on reproductive health in normal males. Clin Sci (Lond) 2001 Jun;100(6):613-618.

Fielden MR et al. Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice. Food Chem Toxicol 2003 Apr;41(4):447-54.

Churella HR et al. Growth and protein status of term infants fed soy protein formulas differing in protein content. J Am Coll Nutr 1994;13:362-267.

Pamela L et al. Phytoestrogens and thyroid cancer risk among woman. Presented in the 4th international symposium on the role of soy in preventing and treating chronic disease, San Diego, CA. 2001 Nov 4-7.

The long term effects of soy-based formula on isoflavone concentration of plasma and urine, and growth and recognition development at 10 and 20 months old infants. Asia Pac J Clin Nutr. 2004;13(Suppl):S123
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