Overview of research articles about isoflavones

A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men. Nestel P et al. Eur J Clin Nutr. 2004 Mar;58(3):403-8

Absorption in humans of isoflavones from soy and red clover is similar. Tsunoda N, Pomeroy S, Nestel P. J Nutr 2002 Aug;132(8):2199-201

Alternative treatments for menopause symptoms. Systematic review of scientific and lay literature. Seidl MM, Stewart DE. Can Fam Physician. 1998 Jun;44:1299-308

Antioxidant activity of phytoestrogenic isoflavones. Ruiz-Larrea MB et al. Free Radic Res. 1997 Jan;26(1):63-70

Antioxidant and antipromotional effects of the soybean isoflavone genistein. Wei H et al. Proc Soc Exp Bio Med 1995 Jan; 208(1)124-130

Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. Chen, Yu-ming et al. Menopause. 11(3):246-254, 2004

Bioavailability of Isoflavones after Ingestion of Soy Beverages in Healthy Adults. Mitsuyoshi Kano, Tomomi Takayanagi, Katsuhisa Harada, Seigo Sawada and Fumiyasu Ishikawa. J. Nutr. 136:2291-2296, September 2006

Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Cassidy A, Bingham S, Setchell KD. Am J Clin Nutr. 1994 Sep;60(3):333-40

Breast and Uterine Effects of Soy Isoflavones and Conjugated Equine Estrogens in Postmenopausal Female Monkeys. Charles E. Wood et al. The Journal of Clinical Endocrinology & Metabolism Vol. 89, No. 7 3462-3468

Chemoprevention by Grape Seed Extract and Genistein in Carcinogen-induced Mammary Cancer in Rats Is Diet Dependent. Kim H, Hall P, Smith M, Kirk M, Prasain JK, Barnes S, Grubbs C.. J. of Nutr. 2004 Dec;134(12):3445S-52S

Chemoprevention of Breast Cancer, Proteomic Discovery of Genistein Action in the Rat Mammary Gland. Craig Rowell, D. Mark Carpenter and Coral A. Lamartiniere. Journal of Nutrition, 135:2953S-2959S, December 2005

Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. Picherit C, Coxam V, Bennetau-Pelissero C, Kati-Coulibaly S, Davicco MJ, Lebecque P and Barlet JP.. J Nutr. 2000 Jul;130(7):1675-81

Dietary isoflavones may protect against prostate cancer in Japanese men. Nagata Y, Sonoda T, Mori M, Miyanaga N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Akaza H. J Nutr. 2007 Aug;137(8):1974-9.

Dietary isoflavones: biological effects and relevance to human health. Setchell KD, Cassidy A. J Nutr. 1999 Mar;129(3):758S-767S

Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer. Ju-Yuan Guo, Xiaosong Li, Jimmy D. Browning, Jr., George E. Rottinghaus, Dennis B. Lubahn, Andreas Constantinou, Maurice Bennink and Ruth S. MacDonald . Journal of Nutrition:179-182, January 2004

Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. Arjmandi BH et all. J Nutr. 1996 Jan;126(1):161-7

Effect of a phytoestrogen food supplement on reproductive health in normal males. Mitchell JH, Cawood E, Kinniburgh D, Provan A, Collins AR, Irvine DS. Clin Sci (Lond). 2001 Jun;100(6):613-8

Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy. Kang X, Zhang Q, Wang S, Huang X, Jin S. CMAJ. 2010 Oct 18

Effects of a soy milk supplement on plasma cholesterol levels and oxidative DNA damage in men--a pilot study. Mitchell JH, Collins AR. Eur J Nutr. 1999 Jun;38(3):143-8

Effects of Estrogen-Progestin on Risk of Fracture and Bone Mineral Density. Jane A. Cauley, John Robbins, Zao Chen, Steven R. Cummings, Rebecca D. Jackson, Andrea Z. LaCroix, Meryl LeBoff, Cora E. Lewis, Joan McGowan, Joan Neuner, Mary Pettinger, Marcia L. Stefanick, Jean Wactawski-Wende, Nelson B. Watts. JAMA. 2003;290:1729-1738

Effects of Phytoestrogens on Bone Turnover in Postmenopausal Women with a History of Breast Cancer. Eini Nikander, Merja Metsä-Heikkilä, Olavi Ylikorkala and Aila Tiitinen . The Journal of Clinical Endocrinology and Metabolism Vol. 89, No. 3 1207-1212

Environmental Influence on Isoflavones and Saponins in Soybeans and Their Role in Colon Cancer. Ruth S. MacDonald et al. Journal of Nutrition 135: 1239-1242, 2005

Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood.. Strom BL, Schinnar R, Ziegler EE, Barnhart KT, Sammel MD, Macones GA, Stallings VA, Drulis JM, Nelson SE and Hanson SA . JAMA. 2001 Aug 15;286(7):807-14

Factors Affecting the Bioavailability of Soy Isoflavones in Humans after Ingestion of Physiologically Relevant Levels from Different Soy Foods. Aedin Cassidy, Jonathan E. Brown, Anne Hawdon, Marian S. Faughnan, Laurence J. King, Joe Millward, Linda Zimmer-Nechemias, Brian Wolfe and Kenneth D.R. Setchell. J. Nutr. 136:45-51, January 2006

Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats. Lihong Bu, Kenneth DR Setchell, and Edwin D Lephart. Reprod Biol Endocrinol. 2005; 3: 58

Intake of Fermented Soybeans, Natto, Is Associated with Reduced Bone Loss in Postmenopausal Women: Japanese Population-Based Osteoporosis (JPOS) Study. Yukihiro Ikeda, Masayuki Iki, Akemi Morita, Etsuko Kajita, Sadanobu Kagamimori, Yoshiko Kagawa and Hideo Yoneshima. Journal of Nutrition. 136:1323-1328, May 2006

Intake of Soy Porducts is Associated with Better Plasma Lipid Profiles in the Hong Kong Chinese Population. Suzanne C. Ho et al. Journal of Nutrition. 2000;130:2590-2593

Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer. Hamilton-Reeves JM, Rebello SA, Thomas W, Slaton JW, Kurzer MS. J Nutr. 2007 Jul;137(7):1769-75

Isoflavones and Functional Foods Alter the Dominant Intestinal Microbiota in Postmenopausal Women. Thomas Clavel, Matteo Fallani, Patricia Lepage, Florence Levenez, Jacinthe Mathey, Violaine Rochet, Michèle Sérézat, Malène Sutren, Gemma Henderson, Catherine Bennetau-Pelissero, Françoise Tondu, Michael Blaut, Joël Doré and Véronique Coxam. Journal of Nutrition 135:2786-2792, December 2005

Isoflavones decrease insomnia in postmenopause. Hachul H, Brandao LC, D'Almeida V, Bittencourt LR, Baracat EC, Tufik S.. Menopause. 2010 Aug 19

Isoflavones from red clover (Promensil) significantly reduce menopause hot flush symptoms compared with placebo. Peter H. M. van de Weijera et al. Peter H. M. van de Weijera et al

Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. Nestel PJ et al. J Clin Endocrinol Metab 1999 Oct;84(10):3647

Isoflavones prevent bone loss following ovariectomy in young adult rats.. Tsuang YH, Chen LT, Chiang CJ, Wu LC, Chiang YF, Chen PY, Sun JS, Wang CC. . Journal of Orthopaedic Surgery and Research 2008, 3:12

Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids. Anderson JW, Johnstone BM, Cook-Newell ME. New England Journal of Medicine. 1995 Aug 3;333(5):276-82

Method of defining equol-producer status and its frequency among vegetarians. Setchell KD, Cole SJ.. J Nutr. 2006 Aug;136(8):2188-93

Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women. E. Anupongsanugool, S. Teekachunhatean, N. Rojanasthien, S. Pongsatha, and C. Sangdee. BMC Clin Pharmacol. 2005 Mar 3;5(1):2

Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. KD Setchell. American Journal of Clinical Nutrition, Vol 68, 1333S-1346S

Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate - isoflavone diet. Pollard M, Wolter W. Prostate 2000 Oct 1;45(2):101-5

Prolonged intake of dietary fermented soybeans (natto) with the reinforced vitamin K2 (menaquinone-7) enhances circulating gamma-carboxylated osteocalcin concentration in normal individuals.. Tsukamtot Y, Ichise H and Yamaguchi M. Journal of Health Science, 51,191-196, 2005

Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Somekawa Y, Chiguchi M, Ishibashi T, Aso T.. Obstet Gynecol. 2001 Jan;97(1):109-15

Soy isoflavone supplementation in healthy men prevents NF-kappaB activation by TNF-alpha in blood lymphocytes. Davis JN et al. Free Radic Biol Med 2001;30:1293-1302

Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : A single-blind randomized, placebo-controlled trial.. Ye YB, Tang XY, Verbruggen MA, Su YX. Eur J Nutr. 2006 Jun 8

Soy isoflavones attenuate human monocyte adhesion to endothelial cell-specific CD54 by inhibiting monocyte CD11a. Nagarajan S, Stewart BW, Badger TM. J Nutr. 2006 Sep;136(9):2384-90

Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Honoré EK. Fertility and Sterility. 1997, 67, 148-154

Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. Rice L, Handayani R, Cui Y, Medrano T, Samedi V, Baker H, Szabo NJ, Rosser CJ, Goodison S, Shiverick KT. J Nutr. 2007 Apr;137(4):964-72

Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. Chen YM et al. J Clin Endocrinol Metab. 2003 Oct;88(10):4740-7

Soy isoflavones in the treatment of prostate cancer. Hussain M et al. Nutr Cancer 2003;47(2):111-7

Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women.. Martin O. Weickert, Manja Reimann, Bärbel Otto, Wendy L. Hall, Katerina Vafeiadou, Jesper Hallund, Marika Ferrari, Duncan Talbot, Francesco Branca, Susanne Gjedsted Bügel, Christine M. Williams, Hans-Joachim Zunft, Corinna Koebnick. Journal of Negative Results in BioMedicine 2006, 5:11

Soy Isoflavones Modulate Azoxymethane-Induced Rat Colon Carcinogenesis Exposed Pre- and Postnatally and Inhibit Growth of DLD-1 Human Colon Adenocarcinoma Cells by Increasing the Expression of Estrogen Receptor-beta.. Raju J, Bielecki A, Caldwell D, Lok E, Taylor M, Kapal K, Curran I, Cooke GM, Bird RP, Mehta R. . J Nutr. 2009 Mar;139(3):474-81

Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Potter SM et al. Am J Clin Nutr. 1998 Dec;68(6 Suppl):1375S-1379S

Soy Protein Containing Isoflavones Reduces the Size of Atherosclerotic Plaques without Affecting Coronary Artery Reactivity in Adult Male Monkeys.. MR Adams, DL Golden, JK Williams, AA Franke, TC Register and JR Kaplan. Journal of Nutrition, December 2005, 135:2852-2856

Soy Protein Has a Greater Effect on Bone in Postmenopausal Women Not on Hormone Replacement Therapy, as Evidenced by Reducing Bone Resorption and Urinary Calcium Excretion. Bahram H. Arjmandi, Dania A. Khalil, Brenda J. Smith, Edralin A. Lucas, Shanil Juma, Mark E. Payton and Robert A. Wild. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 3 1048-1054

Soy, isoflavones, and breast cancer risk in Japan. Seiichiro Yamamoto et al. Journal of the National Cancer Institute, Vol. 95, No. 12, 906-913, June 18, 2003

Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study. Wang Hong Xu, Wei Zheng, Yong Bing Xiang, Zhi Xian Ruan, Jia Rong Cheng, Qi Dai, Yu Tang Gao, Xiao Ou Shu. British Medical Journal, 2004 May 29; 328(7451):1285

Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. J Nutr. 1999 Sep;129(9):1628-35

Soyfood Intake during Adolescence and Subsequent Risk Of Breast Cancer among Chinese Women. Xian Ou Shu, Fan Jin, Qi Dai, Wanqing Wen, John Potter, Lawrence Kushi, Zhixian Ruan, Yu-Tang Gao and Wei Zheng. Cancer Epidemiology, Biomarkers and Prevention. 2001 May;10(5):483-8

The clinical use of a preparation based on phyto-oestrogens in the treatment of menopausal disorders. Russo R, Corosu R. Acta Biomed Ateneo Parmense. 2003 Dec;74(3):137-43

The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Atkinson C et al. Am J Clin Nutr. 2004 Feb;79(2):326-33

The long term effects of soy-based formula on isoflavone concentration of plasma and urine, and growth and recognition development at 10 and 20 months old infants. Ryowon C, Lee JY, Lee HO, Chung SJ, Cho MR, Kim JY, Lee IH. Asia Pac J Clin Nutr. 2004;13(Suppl):S123

The Soybean Isoflavone Genistein Induces Differentiation of MG63 Human Osteosarcoma Osteoblasts.. Morris C, Thorpe J, Ambrosio L and Santin M. Journal of Nutrition. 2006 May;136(5):1166-70

Trifolium pratense (Red Clover) Exhibits Estrogenic Effects In Vivo in Ovariectomized Sprague-Dawley Rats. Joanna E. Burdette, Jianghua Liu, Dan Lantvit, Eula Lim, Nancy Booth, Krishna P. L. Bhat, Samad Hedayat, Richard B. Van Breemen, Andreas I. Constantinou, John M. Pezzuto, Norman R. Farnsworth and Judy L. Bolton . J. Nutr. 132:27-30, 2002

Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Upmalis DH et al. Menopause. 2000 Jul-Aug;7(4):236-42

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